1. Steady-state fever has been produced in normal volunteers by an intravenous priming injection followed by a sustaining infusion of leucocyte pyrogen. During this fever, volumes of up to 550 g blood were withdrawn, and separated into cells and plasma.

2. No febrile responses were observed when on subsequent days the cells or the plasma was re-infused.

3. These findings are compatible with the hypothesis that the inability to detect a circulating pyrogen in patients with inflammatory fever, reflects the difficulty of obtaining sufficiently large volumes of blood.

4. Transfusion of blood is unlikely to be a useful means of establishing whether circulating endogenous pyrogen is concerned in naturally occurring fever.

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