1. The presence of mucopolysaccharides within arterial walls may be associated with the high concentration of sodium ions within this tissue. These polyanions are sensitive to enzymatic depolymerization which results in a loss of the cation binding properties of the molecule.
2. In this study testicular hyaluronidase perfused through isolated arterial segments resulted in a decrease in reactivity of the artery to 65% that of control arteries. Associated with this finding was a 33% decrease in the sodium ion content of the stimulated hyaluronidase-treated artery. When a variety of other sympathetically innervated tissues were treated with hyaluronidase there was no decrease in reactivity or sodium ion content.