1. The renal clearance of salicylate has been measured in two groups of patients undergoing treatment by alkaline diuresis for salicylate poisoning. One group received mannitol and sodium lactate, the other acetazolamide and sodium bicarbonate.
2. The relationship between urine pH and salicylate clearance was found to be the same in both groups and similar to that shown at non-toxic concentrations in the blood by previous workers.
3. The influence of the rate of urine flow on the relationship between salicylate clearance and urine pH was also shown to be similar to that found at non-toxic concentrations in the blood.