1. In ten patients with essential hypertension treated with propranolol (320 mg daily for 4 months) plasma volume and extracellular fluid volume were determined.

2. A significant increase in extracellular fluid volume (ECFV) was found, but there was no significant change in plasma volume.

3. The genesis of the increase found in ECFV is briefly discussed.

Keywords:
hypertension, propranolol, extracellular fluid volume, plasma volume
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© 1972 The Biochemical Society and the Medical Research Society
1972
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