1. The atraumatic technique for estimating human cerebral mean transit-time (CMTT) by antecubital injection of a bolus of non-diffusible radioactive indicator has been improved.

2. The index of CMTT obtained by the new method was of correct magnitude (2·4 ± 1·1 s SD, n = 10) and underwent an appropriate and significant increase (from 2·4 ± 1·4 s SD to 4·4 ± 0·9 s SD, n = 5) in response to a 10 mmHg reduction in arterial Pco2.

Keywords:
cerebral mean transit-time, atraumatic technique, arterial hypocapnia
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© 1972 The Biochemical Society and the Medical Research Society
1972
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