Somatomedin (Sulphation Factor)-Like Activity of Homocystine

1. Homocystine (10 mg/100 ml) has a significant effect on the incorporation of inorganic sulphate by rat costal cartilage in vitro.

2. The characteristic skeletal changes associated with homocystinuria due to defective cystathionine synthetase could therefore be caused by the elevated plasma concentration (1–10 mg/100 ml) of homocystine present in this disease.