1. The effect of intravenous infusion of ethanol on the concentration of plasma free fatty acids (FFA) and triglycerides (TG) and on hepatic triglyceride content was studied in Rhesus monkeys.
2. A minor fall in the plasma FFA was observed after the infusion of ethanol, followed by a rise in FFA which was prevented by a beta-receptor blocking agent.
3. Ethanol administration increased the liver triglyceride level.
4. Prior treatment with a beta-receptor blocking agent which apparently blocked the adrenergic process did not prevent accumulation of triglycerides in the ethanol-treated animals.