1. Experimental hypertension could be induced in rats by injecting angiotensin I or II subcutaneously.
2. Such hypertension lasted for about 1 h after injection.
3. Angiotensin-induced hypertension was enhanced and sustained by salt loading and diminished by salt restriction or spironolactone.
4. Angiotensin-salt hypertension is reversed by transplants of compatible renal medulla subcutaneously.