Renal Prostaglandins: Determinants of Intrarenal Distribution of Blood Flow in the Dog

1. Indomethacin inhibited the synthesis of prostaglandins in isolated blood-perfused canine kidneys.

2. Blood flow to the inner cortex was reduced to a greater degree by indomethacin than blood flow to the outer cortex, resulting in redistribution of fractional blood flow to the outer cortex.

3. A prostaglandin, probably PGE₂, appears to participate in the regulation intra-renally of medullary vascular resistance and thereby inner cortical blood flow.