1. High-salt, high-carbohydrate and low-protein diet induces remarkable elevation of blood pressure in spontaneous hypertensive rats (SHR).
2. These animals have low serum potassium, low blood urea nitrogen and high blood sugar.
3. Heart weight is increased in proportion to the elevation of blood pressure.
4. Kidney weight of rats receiving the high-salt, high-carbohydrate and low-protein diet was, by contrast, smaller than SHR receiving a normal diet.
5. The kidneys of SHR receiving a high-salt, high-protein diet were twice as heavy as the kidneys of normal rats.
6. Similar dietary modifications in Goldblatt hypertensive rats to those in SHR produced similar changes in blood pressure and heart weight.