1. The effect of an 18, 30 or 40 h fast on the rate of purine biosynthesis de novo as measured by the incorporation of [14C]formate into formylglycinamide ribonucleotide during azaserine block has been examined in the rat spleen.

2. There is a reproducible fall in the rate of purine biosynthesis de novo during fasting. Values at 40 h were approximately one-third of the values in the colony-fed non-fasted animals.

3. Re-feeding animals with an amino acid mixture by stomach tube partially reversed the inhibition of purine synthesis induced by a 40 h fast.

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