1. A new technique has been developed for the detection of inborn errors of mucopolysaccharide metabolism by measurement of the incorporation of radioactive sulphate into lymphocytes stimulated by phytohaemagglutinin.
2. Incorporation of 35SO4 was much higher in lymphocytes of patients with mucopolysaccharidosis than in healthy subjects.
3. This technique offers a rapid, simple, reliable screening procedure for the detection of mucopolysaccharidoses.