1. In vitamin D-deficient chicks both vitamin D3 and 1α-hydroxycholecalciferol markedly decrease renal 1-hydroxylase activity and induce 24-hydroxylase activity.

2. Actinomycin D abolishes both effects.

3. These results are consistent with feedback regulation of vitamin D3 metabolism by a direct nuclear action of the vitamin or its metabolites on the kidney cells.

Keywords:
cholecalciferol, 1α,25-dihydroxycholecalciferol, 24,25-dihydroxycholecalciferol, 1α-hydroxycholecalciferol, actinomycin D
This content is only available as a PDF.
© 1975 The Biochemical Society and the Medical Research Society
1975
You do not currently have access to this content.