1. The mechanism by which pretreatment of rats with intracisternal 6-hydroxydopamine prevents the onset of deoxycorticosterone hypertension has been studied.

2. Rats pretreated with central 6-hydroxydopamine increase their consumption of 0.17 mol/l sodium chloride-0.03 mol/l potassium chloride (‘saline’) less than normal rats when implanted with deoxycorticosterone.

3. Intact rats restricted to the equivalent consumption of saline of rats pretreated with 6-hydroxydopamine develop hypertension despite this restriction.

4. It is suggested that the prevention of deoxycorticosterone hypertension by central 6-hydroxydopamine does not depend on reduced saline consumption.

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