1. The effect of propranolol and sotalol on renin secretion was studied in the anaesthetized dog.
2. Beta-adrenergic blockade did not modify basal renin secretion and did not affect the rise of renin secretion induced by haemorrhage or aortic constriction.
3. Beta-adrenergic blockade diminished the rise in renin secretion induced by stimulation of the renal nerves.