1. Twenty-three subjects with essential hypertension were followed for a period of up to 7 years. They were untreated during the investigations.
2. Plasma renin concentration was found to decrease temporarily in some subjects. The ultimate change was a gradual rise. In those subjects who suffered myocardial infarction renin tended to rise more sharply.
3. A relationship was established with the rise in renal vascular resistance, which almost invariably occurred over the years.
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© 1976 The Biochemical Society and the Medical Research Society
1976
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