1. Indomethacin treatment of renomedullary interstitial cells (RIC) causes a marked increase in number and size of their lipid droplets. The anti-hypertensive function is retained.

2. After multiple passages in tissue culture, RIC lose their ability to produce an anti-hypertensive effect in hypertensive animals. Along with this functional loss, lipid droplets and a prominent cisternal system become attenuated or disappear.

3. We conclude that preservation of the lipid granule—cisternal organelle relationship is important in preservation of the anti-hypertensive endocrine function of RIC.

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