1. Acute severe sodium subtraction (20–25% of total exchangeable sodium) before or during treatment with adrenocorticotrophic hormone (ACTH) does little to modify the increase in blood pressure induced by ACTH.
2. Chronic low salt diet, less than 5 mmol/day, abolishes the blood pressure increase, but the response can be restored by increasing the sodium intake to as little as 10 mmol/day.
3. 17α,20α-Dihydroxyprogesterone infused concurrently with other adrenal steroids will mimic ACTH hypertension and perhaps represents a new class of steroid capable of influencing btood pressure.
This content is only available as a PDF.
© 1976 The Biochemical Society and the Medical Research Society
1976
You do not currently have access to this content.