1. A highly specific and sensitive assay based on stable isotope dilution and mass fragmentography has been developed to measure clonidine in plasma.

2. Plasma half-lives of clonidine ranged from 6·9 to 9·4 h in five normotensive subjects.

3. Plasma clonidine concentration correlated with reduction in salivary flow and degree of sedation but not with change in blood pressure.

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