1. Acute hypoxaemia has been reported to stimulate vasopressin release in animals.
2. Hypoxaemia induced by breathing 9·3% oxygen for 15–20 min failed to produce a rise in plasma arginine vasopressin concentration in six out of eight healthy human subjects. The two subjects who developed an increase in plasma arginine vasopressin concentration had a significant rise in serum cortisol.
3. Breathing 100% nitrogen until impairment of consciousness caused no rise in plasma arginine vasopressin concentration.
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© 1977 The Biochemical Society and the Medical Research Society