1. Hypertension was induced in rats by renal artery clip with the contralateral kidney removed (Goldblatt I) or left intact (Goldblatt II).

2. Plasma noradrenaline was increased 62% in the Goldblatt I animals after 3 weeks.

3. Hypothalamic tyrosine hydroxylase and dopamine β-hydroxylase activities, and the concentration of noradrenaline were increased in the Goldblatt I animals after 3 weeks.

4. Enhanced hypothalamic noradrenaline synthesis may be a pathogenic factor in Goldblatt I renovascular hypertension.

Keywords:
dopamine-β-hydroxylase, plasma noradrenaline, renovascular hypertension, tyrosine hydroxylase
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© 1978 The Biochemical Society and the Medical Research Society
1978
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