Changes in Cardiac Output during the Development of Renal Hypertension in Sodium-Depleted Dogs

1. Chronic renovascular hypertension developed in uninephrectomized, sodium-depleted dogs in association with a decrease in cardiac output.

2. With sodium and volume repletion of these animals, cardiac output returned to normal but the high level of arterial pressure was unchanged; consequently, the peripheral arterioles dilated.

3. These observations provide evidence against the theory of whole-body autoregulation.