1. Further observations from an earlier study in which phenobarbitone in a dose of 180 mg daily was administered to ten normal men and women for 3 weeks are reported. There was a significant increase in plasma high-denity-lipoprotein (HDL) cholesterol concentration and in the concentration of both total plasma and low-density-lipoprotein (LDL) apolipoprotein B.

2. There was no change in the ratios of the cholesterol: apolipoprotein B and triglyceride: apolipoprotein B in LDL.

3. There was no significant change in plasma very-low-density-lipoprotein (VLDL) apolipoprotein B concentration and the proportion of lipid and apolipoprotein B in VLDL remained unchanged.

4. There was no change in the ratio of HDL:LDL cholesterol concentrations.

Keywords:
antipyrine clearance, apolipoprotein B, cholesterol, γ-glutamyl transpeptidase, high-density lipoproteins, low-density lipoproteins, microsomal enzyme induction, phenobarbitone, triglycerides, very-low-density lipoproteins
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© 1979 The Biochemical Society and the Medical Research Society
1979
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