1. The properties of a new antihypertensive agent, SK&F 92657, dl-3-[2-(3-t-butylamino-2-hydroxypropoxy)phenyl]-6-hydrazinopyridazine, have been studied.

2. The compound caused a sustained fall in blood pressure in several species as a result of precapillary vasodilatation, particularly in the renal and coronary vasculatures.

3. The β-adrenoreceptor-blocking actions of SK&F 92657 prevent reflex cardiac stimulation.

Keywords:
β-adrenoreceptor blockade, antihypertensive drugs, regional blood flow, SK&F 92657, vasodilatation
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© 1979 The Biochemical Society and the Medical Research Society
1979
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