1. Renin was measured in individual juxtaglomerular apparatuses before and after acidification in vitro..

2. Active renin increased with delivery of extra sodium by microperfusion to the macula densa and this increase was similar to that achieved with acidification.

3. In rats pretreated with an inhibitor of protein synthesis active renin increased when extra sodium was delivered to the macula densa.

4. Salt intake changed the amount of renin present in the juxtaglomerular apparatus. In rats on a high salt intake the total renin was low and was all in an active form.

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