1. In eight hypertensive diabetic subjects receiving hydrochlorothiazide, glucose homeostasis as measured by the changes in plasma glucose, insulin and glucagon after an oral glucose load was not significantly affected by 8 weeks of therapy with metoprolol.

2. The combination of metoprolol plus hydrochlorothiazide significantly lowered blood pressure in all subjects.

3. Plasma renin activity was suppressed by therapy with metoprolol.

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