1. We have measured adenosine 5′-triphosphate (ATP) levels in isolated leucocyte suspensions from patients with renal failure.

2. Leucocyte ATP is reduced in these patients, unlike erythrocyte ATP which is known to be elevated in uraemia.

3. The relevance of reduced leucocyte ATP to the abnormalities of cation transport and cell function which occur in uraemia is discussed.

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