1. Blood pressure measurements were made in hypertensive subjects after single intravenous and oral doses of labetalol and subsequently during chronic administration.
2. Oral therapy can be as effective as intravenous therapy in achieving acute blood pressure reduction.
3. Blood pressure control with chronic labetalol monotherapy was satisfactory in 11 of the 12 subjects.
4. High dose therapy with labetalol and 49 diuretic produced greater postural blood pressure falls.