1. AMP, ADP, ATP, IMP, GDP, GTP and adenylosuccinate have been measured by high pressure liquid chromatography in three types of animal muscular dystrophy and in a human patient with Duchenne muscular dystrophy.

2. Abnormalities in nucleotide content varied from one dystrophy to another.

3. In each case, however, the ratio [total adenine nucleotide + IMP]/[total guanine nuclotides] was lower in dystrophic muscle, even when severely exercised or ischaemic muscles were used.

4. The practical advantages of this assay for diagnosis of muscular dystrophy are discussed.

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