1. The oral administration of 2·5 mg of the dopamine (3,4-dihydroxyphenethylamine) agonist bromoergocriptine enhanced the osmotically stimulated rise in plasma [arginine]vasopressin ([Arg]VP) concentrations in five normal human subjects.

2. This finding lends support to the suggestion that the osmotically induced release of [Arg]VP is under dopaminergic control in man.

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