1. The effect of an intravenous infusion of insulin [2.5 units h−1 (m2 of body surface area)−1] on the rise in blood pressure and plasma aldosterone after intravenous angiotensin II (5, 10, and 20 ng min−1 kg−1) was investigated in six healthy, sodium-loaded men.

2. Serum insulin reached 96.8 ± 18.1 μ-units/ml (control: 7.0 ± 1.5 μ-units/ml) and serum potassium fell from 4.2 ± 0.2 mmol/l to 3.6 ± 0.2 mmol/l (P < 0.005).

3. Hyperinsulinaemia increased (P < 0.05) the secretion of aldosterone during the largest dose of angiotensin II (20 ng min−1 kg−1), but had no effect on the rise in blood pressure after angiotensin II.

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