Background: Feldberg & Kellaway  were the first to demonstrate the formation and release from envenomed dog and monkey lungs of a substance which caused a delayed and slow contraction of the guinea-pig jejunum; subsequently, Kellaway & Trethewie  described release of a slow-reacting substance (SRS) during acute anaphylaxis of the guinea-pig lung. Brocklehurst [3, 4] later reported the formation of an SRS, which he called slow-reacting substance of anaphylaxis (SRS-A), during anaphylaxis of guinea-pig, rabbit, monkey and human lungs. This substance had similar activity to SRS on guinea-pig ileum and was unaffected by the newly developed antihistamine, mepyramine. Release of SRS-A was demonstrated during antigen-induced constriction of bronchioles from subjects with asthma , suggesting that SRS-A might be of importance in the pathogenesis of human asthma [6, 7]. The development of techniques for the generation and partial purification of SRS-A from the rat peritoneal cavity  and intact guinea-pig lungs  permitted characterization of its biological properties.
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A. G. Leitch; Leukotrienes and the Lung. Clin Sci (Lond) 1 August 1984; 67 (2): 153–160. doi: https://doi.org/10.1042/cs0670153
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