1. Blood ethanol and acetaldehyde concentrations were compared in normal young male and female subjects after intravenous infusion of 0.5 g of ethanol/kg body weight.

2. After the infusion was completed, females had significantly higher mean concentrations of blood ethanol than males, but a significantly lower apparent volume of distribution (Vd) of ethanol (0.56 ± 0.06 l/kg vs 0.68 ± 0.17 l/kg, P<0.05). There were no differences in ethanol elimination rate (EER) (females 1.78 ± 0.3 mmol h−1 kg−1; males 1.87 ± 0.41 mmol h−1 kg−1). The mean value of the areas under the acetaldehyde/time curves (AUC) were significantly greater for males (88.5 ± 26.4 μmol/l. h) than for females (58.6 ± 31.5 μmol/l. h, P<0.05).

3. Since the ethanol elimination rate was similar in both sexes, the observed differences in AUC for acetaldehyde may reflect the sex differences in metabolism of this substrate by the liver.

This content is only available as a PDF.
You do not currently have access to this content.