The dicarboxylic amino acids, glutamate and aspartate, are excitatory neurotransmitters in many brain regions. Recent animal experiments with analogues of dicarboxylic amino acids that block their excitatory actions, suggest that such selective antagonists could have important therapeutic uses in neurology and psychiatry. The strongest evidence concerns epilepsy and disorders of the motor system. However, there are theoretical and experimental grounds for studying therapeutic applications in cerebral ischaemia and in chronic degenerative disorders. This review summarizes the experimental background, and proposes some key future studies.
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Other| February 01 1985
Possible Therapeutic Applications of Antagonists of Excitatory Amino acid Neurotransmitters
Publisher: Portland Press Ltd
Online ISSN: 1470-8736
Print ISSN: 0143-5221
© 1985 The Biochemical Society and the Medical Research Society
Clin Sci (Lond) (1985) 68 (2): 113–122.
Brian Meldrum; Possible Therapeutic Applications of Antagonists of Excitatory Amino acid Neurotransmitters. Clin Sci (Lond) 1 February 1985; 68 (2): 113–122. doi: https://doi.org/10.1042/cs0680113
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