1. A Workshop on α-Adrenoceptors was held at Loch Lomond, Scotland in July 1984. Forty participants from different disciplines in the pharmacological, biochemical, physiological and clinical fields considered the questions:

(i) How many subtypes of α-receptor do we need at present?

(ii) What are the activation steps set in motion by α-adrenoceptors?

(iii) What are the physiological roles of α-adrenoceptors in circulatory control?

(iv) What are the pathophysiological roles and how can α-receptors be manipulated in disease?

2. This paper reviews the major points which arose and is intended as a guide to the papers in this Supplement.

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