1. To examine the response of renal prostaglandins (PG) to systemic and renal vasoconstriction noradrenaline (NA), arginine vasopressin (AVP) and angiotensin II (ANG II) were each infused into eight healthy female subjects for 3 h on different days. Urinary excretion of PGE2, PGF and 6-keto-PGF was determined hourly.

2. NA and ANG II stimulated excretion of PGF significantly, but not of PGE2 or 6-keto-PGF AVP stimulated renal PGF and 6-keto-PGF significantly, but not PGE2.

3. A weak correlation was found between urinary PGF and diastolic blood pressure during NA and ANG II infusions, but not during AVP infusion.

4. The release of renal PG does not appear to constitute an obligatory and concomitant response to the blood pressure rise induced by the pressor agonists. The greater response of PGF than of PGE2 may result from a preferential direct effect on PGF secretion or from an increased conversion of PGE2 into F.

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