1. A genetic polymorphism of apolipoprotein (apo) C-III was studied in 49 Caucasian patients with extra-coronary atherosclerosis demonstrated by angiography.

2. Twelve patients (24%) possessed an uncommon allelic variant of the apo A-I/C-III gene cluster compared with two (4%) in 50 healthy controls (P < 0.01).

3. Of 27 patients with carotid atherosclerosis, 22% had the uncommon genotype (P < 0.02), and in aortofemoral atherosclerosis (n = 22) 27% possessed the uncommon variant (P < 0.01).

4. When normotriglyceridaemic subgroups (n = 32) with arterial disease were studied the difference in genotype frequencies persisted, 22% having the uncommon allele (P < 0.01), suggesting that such genetic variants have effects independent of circulating levels of plasma lipids.

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