1. We have investigated the frequencies of the major histocompatibility complex class II alleles by restriction fragment length polymorphism analysis, using DR, DQ and DP complementary DNA probes, in 40 Caucasoid steroid-sensitive nephrotic children.

2. A significant association with HLA-DR7 was demonstrated (P = 2 × 10−5; aetiological fraction 0.6). The DQB1 gene of HLA-DQw2 was present in 83% of our patients (P = 2 × 10−4; aetiological fraction 0.7). We present evidence that it contributes a second susceptibility allele.

3. A weak association between the uncommon HLA-DP-Cp63 allele and the disease was also observed.

4. Our data suggest that the immune events in steroid-sensitive nephrotic syndrome are defined by a particular immunogenetic background involving the β-chain genes of HLA-DR7 and HLA-DQw2.

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