1. Simultaneous 24 h intragastric acidity and plasma gastrin concentration profiles were determined in 35 healthy young women and 96 healthy young men.

2. The females had a consistently lower median hourly intragastric acidity, and a higher median hourly plasma gastrin concentration, throughout the 24 h.

3. The 24 h integrated intragastric acidity was significantly lower in the female group (females, 485 mmol · h · l−1; males, 842 mmol · h · l−1; P < 0.001). The 24 h integrated plasma gastrin concentration was significantly higher in the female group (females, 407 pmol · h · l−1; males, 185 pmol · h · l−1; P < 0.001).

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