Nitric oxide exerts multiple effects on renal function. It remains unclear whether endogenous nitric oxide production is increased or decreased in patients with chronic renal failure. To evaluate endogenous nitric oxide production in these patients we studied exhaled nitric oxide output by an ozone chemiluminescence method and plasma NO2-/NO3- levels by the Griess method in 40 patients with end-stage chronic renal failure who underwent regular continuous ambulatory peritoneal dialysis (n = 30) or haemodialysis (n = 10), and in 28 healthy subjects. Patients with chronic renal failure had a higher exhaled nitric oxide concentration [39±3 versus 19±1 parts per billion, (mean±S.E.M.), P< 0.0001], a greater nitric oxide output (177±11 versus 96±7 ;nl·min-1·m-2, P< 0.001) and a higher plasma NO2-/NO3- concentration (96±14 versus 33±4 ;μmol, P< 0.01) than controls. These values did not differ between patients on haemodialysis and those on continuous ambulatory peritoneal dialysis. Patients with chronic renal failure had significantly higher plasma concentrations of both interleukin-1β and interferon-γ than controls. The exhaled nitric oxide output did not correlate with plasma NO2-/NO3- or with peritoneal dialysate NO2-/NO3-, but plasma NO2-/NO3- correlated with dialysate NO2-/NO3- in patients who underwent continuous ambulatory peritoneal dialysis (r = 0.77, P< 0.01). Haemodialysis for 4 ;h acutely decreased plasma NO2-/NO3- (92±17 versus 50±8 ;μmol, P< 0.05) and cGMP concentration (16.5±4.3 versus 5.1±1.7 ;pmol/ml, P< 0.01), but did not decrease exhaled nitric oxide output. The increase in exhaled nitric oxide with the simultaneous increase in circulating cytokines suggests that nitric oxide synthase seems to be induced significantly in patients with chronic renal failure. Increased endogenous nitric oxide production may have a pathophysiological role in patients with uraemia.
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Research Article|
January 01 1999
Increased excretion of nitric oxide in exhaled air of patients with chronic renal failure
Akihiro MATSUMOTO;
Akihiro MATSUMOTO
1The Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, 7–3–1 Hongo, Bunkyo-ku, Tokyo 113, Japan
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Yasunobu HIRATA;
1The Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, 7–3–1 Hongo, Bunkyo-ku, Tokyo 113, Japan
Correspondence: Dr Y. Hirata.
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Masao KAKOKI;
Masao KAKOKI
1The Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, 7–3–1 Hongo, Bunkyo-ku, Tokyo 113, Japan
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Daisuke NAGATA;
Daisuke NAGATA
1The Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, 7–3–1 Hongo, Bunkyo-ku, Tokyo 113, Japan
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Shin-ichi MOMOMURA;
Shin-ichi MOMOMURA
1The Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, 7–3–1 Hongo, Bunkyo-ku, Tokyo 113, Japan
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Tokuichiro SUGIMOTO;
Tokuichiro SUGIMOTO
*Nephrology Department of Internal Medicine, Mitsui Memorial Hospital, Tokyo 101, Japan
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Hitoshi TAGAWA;
Hitoshi TAGAWA
*Nephrology Department of Internal Medicine, Mitsui Memorial Hospital, Tokyo 101, Japan
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Masao OMATA
Masao OMATA
1The Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, 7–3–1 Hongo, Bunkyo-ku, Tokyo 113, Japan
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Publisher: Portland Press Ltd
Received:
February 09 1998
Revision Received:
June 24 1998
Accepted:
July 27 1998
Online ISSN: 1470-8736
Print ISSN: 0143-5221
The Biochemical Society and the Medical Research Society © 1999
1999
Clin Sci (Lond) (1998) 96 (1): 67–74.
Article history
Received:
February 09 1998
Revision Received:
June 24 1998
Accepted:
July 27 1998
Citation
Akihiro MATSUMOTO, Yasunobu HIRATA, Masao KAKOKI, Daisuke NAGATA, Shin-ichi MOMOMURA, Tokuichiro SUGIMOTO, Hitoshi TAGAWA, Masao OMATA; Increased excretion of nitric oxide in exhaled air of patients with chronic renal failure. Clin Sci (Lond) 1 January 1998; 96 (1): 67–74. doi: https://doi.org/10.1042/cs0960067
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