The level of the acute-phase response is a major predictor of survival in patients with advanced pancreatic cancer. This study examines the association between the acute-phase protein response, as determined by serum C-reactive protein, and serum levels of interleukin-6, soluble interleukin-6 receptor and the soluble tumour necrosis factor receptors in patients with pancreatic cancer. Thirty-four blood samples were collected from 13 patients with advanced pancreatic cancer. Samples were also collected from six healthy subjects. Levels of C-reactive protein, interleukin-6, soluble interleukin-6 receptor and soluble tumour necrosis factor receptors 55 and 75 were measured by indirect ELISA. Serum levels of C-reactive protein, interleukin-6 and soluble tumour necrosis factor receptors 55 and 75 were significantly higher in cancer patients than in controls. Levels of serum soluble interleukin-6 receptor were not significantly different between the two groups. In cancer patients, a significant positive association was found between the level of the acute-phase protein response and serum levels of interleukin-6, soluble tumour necrosis factor receptor 55 and soluble tumour necrosis factor receptor 75. No association was found between levels of soluble interleukin-6 receptor and any other factor. There is no significant relationship between the level of soluble interleukin-6 receptor and the acute-phase protein response in vivo and the biological role of soluble interleukin-6 receptor in the chronic inflammatory component of cachexia remains unclear.
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January 1998
Research Article|
January 01 1999
Relationship of serum levels of interleukin-6, soluble interleukin-6 receptor and tumour necrosis factor receptors to the acute-phase protein response in advanced pancreatic cancer
Matthew D. BARBER;
Matthew D. BARBER
1University Department of Surgery, Royal Infirmary of Edinburgh, Edinburgh EH3 9YW, Scotland, U.K.
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Kenneth C. H. FEARON;
Kenneth C. H. FEARON
1University Department of Surgery, Royal Infirmary of Edinburgh, Edinburgh EH3 9YW, Scotland, U.K.
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James A. ROSS
1University Department of Surgery, Royal Infirmary of Edinburgh, Edinburgh EH3 9YW, Scotland, U.K.
Correspondence: Dr J. A. Ross.
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Clin Sci (Lond) (1998) 96 (1): 83–87.
Article history
Received:
May 14 1998
Revision Received:
July 31 1998
Accepted:
August 12 1998
Citation
Matthew D. BARBER, Kenneth C. H. FEARON, James A. ROSS; Relationship of serum levels of interleukin-6, soluble interleukin-6 receptor and tumour necrosis factor receptors to the acute-phase protein response in advanced pancreatic cancer. Clin Sci (Lond) 1 January 1998; 96 (1): 83–87. doi: https://doi.org/10.1042/cs0960083
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