The tissue concentration of lipid hydroperoxides, which was determined by a specific method involving chemical derivatization and HPLC, increased significantly in the heart, liver, kidney and muscle of diabetic rats 8 weeks after the intraperitoneal injection of streptozotocin compared with that of the control group. These results demonstrate that an enhanced oxidative stress is caused in these tissues by diabetes. Vitamin C concentrations of the brain, heart, lung, liver, kidney and plasma of the diabetic rats decreased significantly after 8 weeks compared with those of the control group. Vitamin E concentrations of the brain, heart, liver, kidney, muscle and plasma of the diabetic rats increased significantly after 4 weeks compared with the control group. After 8 weeks, an elevation in vitamin E concentration was observed in the heart, liver, muscle and plasma of the diabetic rats.
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February 1999
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Research Article|
February 01 1999
Change in tissue concentrations of lipid hydroperoxides, vitamin C and vitamin E in rats with streptozotocin-induced diabetes
Fang SUN;
Fang SUN
1Department of Food Science and Nutrition, Nara Women's University, Nara 630–8506, Japan
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Kozue IWAGUCHI;
Kozue IWAGUCHI
1Department of Food Science and Nutrition, Nara Women's University, Nara 630–8506, Japan
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Reiko SHUDO;
Reiko SHUDO
1Department of Food Science and Nutrition, Nara Women's University, Nara 630–8506, Japan
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Yoshie NAGAKI;
Yoshie NAGAKI
1Department of Food Science and Nutrition, Nara Women's University, Nara 630–8506, Japan
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Kyoko TANAKA;
Kyoko TANAKA
1Department of Food Science and Nutrition, Nara Women's University, Nara 630–8506, Japan
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Kazumi IKEDA;
Kazumi IKEDA
1Department of Food Science and Nutrition, Nara Women's University, Nara 630–8506, Japan
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Sadako TOKUMARU;
Sadako TOKUMARU
*Department of Life and Health Sciences, Joetsu University of Education, Joetsu, Niigata 943–8512 Japan
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Shosuke KOJO
1Department of Food Science and Nutrition, Nara Women's University, Nara 630–8506, Japan
Correspondence: Dr Shosuke Kojo.
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Clin Sci (Lond) (1999) 96 (2): 185–190.
Article history
Received:
May 20 1998
Revision Received:
July 15 1998
Accepted:
August 28 1998
Citation
Fang SUN, Kozue IWAGUCHI, Reiko SHUDO, Yoshie NAGAKI, Kyoko TANAKA, Kazumi IKEDA, Sadako TOKUMARU, Shosuke KOJO; Change in tissue concentrations of lipid hydroperoxides, vitamin C and vitamin E in rats with streptozotocin-induced diabetes. Clin Sci (Lond) 1 February 1999; 96 (2): 185–190. doi: https://doi.org/10.1042/cs0960185
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