Leptin is an adipocyte-derived signalling molecule which plays a key role in the regulation of body weight and energy expenditure. Since its involvement in human eating behaviour is still poorly understood, we investigated whether the perception of palatability of food was related to fasting serum leptin levels. Twenty-six non-diabetic subjects, six men and twenty women of widely ranging age and body mass index, performed a standardized high-carbohydrate breakfast test. Palatability was evaluated with a visual analogue scale, body composition by bioelectrical impedance, serum leptin and plasma insulin by radioimmunoassay. Palatability was correlated to fasting serum leptin levels independently of body mass index, body fat mass and percentage of body fat (P< 0.01). No significant relation was observed with peaks of insulinaemia, integrated concentrations of insulin or insulin resistance indices. A stepwise regression analysis indicated that serum leptin gave the strongest predictive association with palatability. These results suggest that the leptin system may be involved in the regulation of human eating behaviour in relation to the perception of palatability of food.
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April 01 1999
Serum leptin is associated with the perception of palatability during a standardized high-carbohydrate breakfast test
Eric RAYNAUD;
*Unité d'Exploration Métabolique – CERAMM, Hôpital Lapeyronie, 371 Avenue Doyen Gaston Giraud, 34295 Montpellier Cedex 5, France
†Laboratoire de Biochimie, Faculté de Pharmacie, 15 Avenue Charles Flahault, 34060 Montpellier Cedex 2, France
Correspondence: Dr E. Raynaud, Unité d'Exploration Métabolique ± CERAMM, Hôpital Lapeyronie, 371 Avenue Doyen Gaston Giraud, 34295 Montpellier Cedex 5, France.
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Jean-Frédéric BRUN;
Jean-Frédéric BRUN
*Unité d'Exploration Métabolique – CERAMM, Hôpital Lapeyronie, 371 Avenue Doyen Gaston Giraud, 34295 Montpellier Cedex 5, France
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Antonia PEREZ-MARTIN;
Antonia PEREZ-MARTIN
*Unité d'Exploration Métabolique – CERAMM, Hôpital Lapeyronie, 371 Avenue Doyen Gaston Giraud, 34295 Montpellier Cedex 5, France
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Colette SAGNES;
Colette SAGNES
*Unité d'Exploration Métabolique – CERAMM, Hôpital Lapeyronie, 371 Avenue Doyen Gaston Giraud, 34295 Montpellier Cedex 5, France
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Anne-Marie BOULARAN;
Anne-Marie BOULARAN
‡Laboratoire de Biochimie A, Hôpital Lapeyronie, 371 Avenue Doyen Gaston Giraud, 34295 Montpellier Cedex 5, France
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Christine FEDOU;
Christine FEDOU
*Unité d'Exploration Métabolique – CERAMM, Hôpital Lapeyronie, 371 Avenue Doyen Gaston Giraud, 34295 Montpellier Cedex 5, France
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Jacques MERCIER
Jacques MERCIER
*Unité d'Exploration Métabolique – CERAMM, Hôpital Lapeyronie, 371 Avenue Doyen Gaston Giraud, 34295 Montpellier Cedex 5, France
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Publisher: Portland Press Ltd
Online ISSN: 1470-8736
Print ISSN: 0143-5221
The Biochemical Society and the Medical Research Society © 1999
1999
Clin Sci (Lond) (1999) 96 (4): 343–348.
Citation
Eric RAYNAUD, Jean-Frédéric BRUN, Antonia PEREZ-MARTIN, Colette SAGNES, Anne-Marie BOULARAN, Christine FEDOU, Jacques MERCIER; Serum leptin is associated with the perception of palatability during a standardized high-carbohydrate breakfast test. Clin Sci (Lond) 1 April 1999; 96 (4): 343–348. doi: https://doi.org/10.1042/cs0960343
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