Recent studies have documented a relationship between increased morbidity and mortality from cardiovascular diseases and a history of weight cycling (WC) in obese subjects. We performed a cross-sectional analysis in 96 weight-cycling android obese women, matched with 96 non-weight-cycling android obese women by age, body mass index (BMI) and waist-to-hip ratio (WHR), to evaluate any increase in blood pressure (BP) levels in association with WC. The patients were all between 20 and 45 years old, were non-menopausal, did not smoke, did not take any medication, had normal glucose tolerance and were otherwise healthy. A history of WC was established on the basis of at least five weight losses in the previous 5 years due to dieting, with a weight loss of at least 4.5 kg per cycle. We documented higher levels of casual BP in the weight-cycling obese compared with the non-weight-cycling subjects: 147±12/90±8 mmHg versus 125±14/79±8 mmHg (P < 0.001). The women with WC showed a statistically significant positive correlation between BP and age, weight, BMI, waist circumference, WHR, total weight regained and weight cycling index (WCI). However, in a multiple regression model only the WHR and WCI contributed significantly to the BP variability. These findings could support the hypothesis that it is the combined exposure of central-type obesity and WC that strongly raises the prediction of hypertension.
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Rapid Communication| May 20 1999
Weight fluctuations could increase blood pressure in android obese women
M. T. GUAGNANO ;
V. PACE-PALITTI ;
C. CARRABS ;
D. MERLITTI ;
Clin Sci (Lond) (1999) 96 (6): 677–680.
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M. T. GUAGNANO, V. PACE-PALITTI, C. CARRABS, D. MERLITTI, S. SENSI; Weight fluctuations could increase blood pressure in android obese women. Clin Sci (Lond) 1 June 1999; 96 (6): 677–680. doi: https://doi.org/10.1042/cs0960677
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