The semicarbazide-sensitive amine oxidases constitute a group of copper-containing enzymes whose physiological function is unclear. The enzymes are present in various tissues, including blood plasma. At present, the source of the plasma enzyme in humans is not known. Results of a recent study suggested that semicarbazide-sensitive amine oxidase is expressed in the skeleton, e.g. in the spine. Using an indirect autoradiographic method in mice, we provide evidence that semicarbazide-sensitive amine oxidase is present in high abundance in bone tissue. Specific activities of semicarbazide-sensitive amine oxidase were estimated in blood samples from subjects with femoral bone fractures. Moreover, enzyme activities were also measured in patients suffering from prostate cancer with skeletal metastases. The level of specific semicarbazide-sensitive amine oxidase activity in serum was significantly elevated in patients with skeletal metastases compared with both healthy controls and patients having prostate cancer without signs of skeletal metastases. Based on the results of the present study, we propose that semicarbazide-sensitive amine oxidase in blood plasma may originate, at least in part, from the skeleton.
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June 04 1999
Elevated activity of semicarbazide-sensitive amine oxidase in blood from patients with skeletal metastases of prostate cancer
Jonas EKBLOM;
Jonas EKBLOM
*Department of Neuroscience, Unit of Pharmacology, UppsalaUniversity, Biomedical Center, Uppsala, Sweden
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Jenny GRÖNVALL;
Jenny GRÖNVALL
*Department of Neuroscience, Unit of Pharmacology, UppsalaUniversity, Biomedical Center, Uppsala, Sweden
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Bo LENNERNÄST;
Bo LENNERNÄST
†Departmentof Oncology, Sahlgrenska University Hospital, Gothenburg, Sweden
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Sten NILSSON;
Sten NILSSON
‡Department of Oncology, Radiology and ClinicalImmunology, Uppsala University, Biomedical Center, Uppsala, Sweden
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Håkan GARPENSTRAND;
Håkan GARPENSTRAND
*Department of Neuroscience, Unit of Pharmacology, UppsalaUniversity, Biomedical Center, Uppsala, Sweden
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Lars ORELAND
Lars ORELAND
*Department of Neuroscience, Unit of Pharmacology, UppsalaUniversity, Biomedical Center, Uppsala, Sweden
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Publisher: Portland Press Ltd
Received:
January 06 1999
Revision Received:
March 05 1999
Accepted:
April 09 1999
Online ISSN: 1470-8736
Print ISSN: 0143-5221
The Biochemical Society and the Medical Research Society © 1999
1999
Clin Sci (Lond) (1999) 97 (1): 111–115.
Article history
Received:
January 06 1999
Revision Received:
March 05 1999
Accepted:
April 09 1999
Connected Content
A correction has been published:
Elevated activity of semicarbazide-sensitive amine oxidase in blood from patients with skeletal metastases of prostate cancer
Citation
Jonas EKBLOM, Jenny GRÖNVALL, Bo LENNERNÄST, Sten NILSSON, Håkan GARPENSTRAND, Lars ORELAND; Elevated activity of semicarbazide-sensitive amine oxidase in blood from patients with skeletal metastases of prostate cancer. Clin Sci (Lond) 1 July 1999; 97 (1): 111–115. doi: https://doi.org/10.1042/cs0970111
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