In cirrhosis there is a hyperdynamic circulation, which occurs mainly in the systemic and splanchnic regions. Using isolated-vessel models, previous studies have shown reduced aortic reactivity to vasoconstrictors in rats with cirrhosis. The aim of the present study was to evaluate and compare the vascular responsiveness to phenylephrine in arterial rings and the blood flows from different regions in rats with cirrhosis and controls. Reactivity was studied in isolated thoracic aortic, superior mesenteric arterial and carotid arterial rings from sham-operated and bile-duct-ligated rats by measuring the cumulative concentration-dependent tension induced by phenylephrine (10-9–10-4 M). Blood flows were measured by the radioactive microsphere method. In rats with cirrhosis, a significant hyporeactivity to phenylephrine was observed in both the aorta and the superior mesenteric artery compared with the corresponding arteries of normal rats. This hyporesponsiveness was corrected by Nω-nitro-l-arginine (0.1 mM). In contrast, carotid artery reactivity and the responses to Nω-nitro-l-arginine were similar in the cirrhotic and control groups. In each case, cardiac output and mesenteric arterial blood flow were significantly higher in cirrhotic than in normal rats. Cerebral blood flows were not significantly different between the two groups. In cirrhotic rats, arterial hyporeactivity may be a consequence of increased regional blood flow and increased production of nitric oxide.
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July 21 1999
Relationship between vascular reactivity in vitro and blood flows in rats with cirrhosis
Dominique PATERON;
*Laboratoire d'Hémodynamique Splanchnique et de Biologie Vasculaire, INSERM U-481, Hôpital Beaujon, 92118 Clichy, France
Correspondence: Dr D. Pateron.
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Frédéric OBERTI;
Frédéric OBERTI
†Laboratoire d'Hémodynamique Splanchnique, Angers, France
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Pascale LEFILLIATRE;
Pascale LEFILLIATRE
*Laboratoire d'Hémodynamique Splanchnique et de Biologie Vasculaire, INSERM U-481, Hôpital Beaujon, 92118 Clichy, France
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Nary VEAL;
Nary VEAL
†Laboratoire d'Hémodynamique Splanchnique, Angers, France
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Khalid A. TAZI;
Khalid A. TAZI
*Laboratoire d'Hémodynamique Splanchnique et de Biologie Vasculaire, INSERM U-481, Hôpital Beaujon, 92118 Clichy, France
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Philippe SOGNI;
Philippe SOGNI
*Laboratoire d'Hémodynamique Splanchnique et de Biologie Vasculaire, INSERM U-481, Hôpital Beaujon, 92118 Clichy, France
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Odile POIREL;
Odile POIREL
*Laboratoire d'Hémodynamique Splanchnique et de Biologie Vasculaire, INSERM U-481, Hôpital Beaujon, 92118 Clichy, France
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Jörg HELLER;
Jörg HELLER
*Laboratoire d'Hémodynamique Splanchnique et de Biologie Vasculaire, INSERM U-481, Hôpital Beaujon, 92118 Clichy, France
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Richard MOREAU;
Richard MOREAU
*Laboratoire d'Hémodynamique Splanchnique et de Biologie Vasculaire, INSERM U-481, Hôpital Beaujon, 92118 Clichy, France
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Paul CALES;
Paul CALES
†Laboratoire d'Hémodynamique Splanchnique, Angers, France
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Didier LEBREC
Didier LEBREC
*Laboratoire d'Hémodynamique Splanchnique et de Biologie Vasculaire, INSERM U-481, Hôpital Beaujon, 92118 Clichy, France
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Publisher: Portland Press Ltd
Received:
February 18 1999
Revision Received:
April 15 1999
Accepted:
May 28 1999
Online ISSN: 1470-8736
Print ISSN: 0143-5221
The Biochemical Society and the Medical Research Society © 1999
1999
Clin Sci (Lond) (1999) 97 (3): 313–318.
Article history
Received:
February 18 1999
Revision Received:
April 15 1999
Accepted:
May 28 1999
Citation
Dominique PATERON, Frédéric OBERTI, Pascale LEFILLIATRE, Nary VEAL, Khalid A. TAZI, Philippe SOGNI, Odile POIREL, Jörg HELLER, Richard MOREAU, Paul CALES, Didier LEBREC; Relationship between vascular reactivity in vitro and blood flows in rats with cirrhosis. Clin Sci (Lond) 1 September 1999; 97 (3): 313–318. doi: https://doi.org/10.1042/cs0970313
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