Airway remodelling, which is manifested by thickening of bronchial wall, is an important causative factor of bronchial hyper-responsiveness in asthma. The pathophysiological mechanism of airway remodelling is not clear. In the present study we evaluated the relationship between nitric oxide (NO) generation and airway wall thickening in patients with chronic asthma. As a marker of NO production, the levels of nitrite/nitrate were measured in induced sputum, and bronchial wall thickening was measured by high-resolution computed tomography. Sputum concentrations of nitrite/nitrate were significantly increased in asthmatic patients compared with controls. The ratio of airway wall thickness to lumen diameter was significantly correlated with the sputum concentration of nitrite/nitrate. Although statistical correlation does not prove causation, this finding suggests that NO may play a key role in the pathogenesis of airway remodelling.
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February 09 2000
Role of nitric oxide in airway remodelling
Esteban C. GABAZZA;
*Third Department of Internal Medicine, Mie University School of Medicine, Edobashi 2-174, Tsu City, Mie Prefecture 514-8507, Japan
Correspondence: Dr. Esteban C. Gabazza (e-mail [email protected]).
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Osamu TAGUCHI;
Osamu TAGUCHI
*Third Department of Internal Medicine, Mie University School of Medicine, Edobashi 2-174, Tsu City, Mie Prefecture 514-8507, Japan
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Shigenori TAMAKI;
Shigenori TAMAKI
*Third Department of Internal Medicine, Mie University School of Medicine, Edobashi 2-174, Tsu City, Mie Prefecture 514-8507, Japan
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Shuichi MURASHIMA;
Shuichi MURASHIMA
†Department of Radiology, Mie University School of Medicine, Edobashi 2-174, Tsu City, Mie Prefecture 514-8507, Japan
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Hiroyasu KOBAYASHI;
Hiroyasu KOBAYASHI
*Third Department of Internal Medicine, Mie University School of Medicine, Edobashi 2-174, Tsu City, Mie Prefecture 514-8507, Japan
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Hiroki YASUI;
Hiroki YASUI
*Third Department of Internal Medicine, Mie University School of Medicine, Edobashi 2-174, Tsu City, Mie Prefecture 514-8507, Japan
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Tetsu KOBAYASHI;
Tetsu KOBAYASHI
*Third Department of Internal Medicine, Mie University School of Medicine, Edobashi 2-174, Tsu City, Mie Prefecture 514-8507, Japan
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Osamu HATAJI;
Osamu HATAJI
*Third Department of Internal Medicine, Mie University School of Medicine, Edobashi 2-174, Tsu City, Mie Prefecture 514-8507, Japan
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Yukihiko ADACHI
Yukihiko ADACHI
*Third Department of Internal Medicine, Mie University School of Medicine, Edobashi 2-174, Tsu City, Mie Prefecture 514-8507, Japan
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Publisher: Portland Press Ltd
Received:
May 17 1999
Revision Received:
October 01 1999
Accepted:
November 25 1999
Online ISSN: 1470-8736
Print ISSN: 0143-5221
The Biochemical Society and the Medical Research Society © 2000
2000
Clin Sci (Lond) (2000) 98 (3): 291–294.
Article history
Received:
May 17 1999
Revision Received:
October 01 1999
Accepted:
November 25 1999
Citation
Esteban C. GABAZZA, Osamu TAGUCHI, Shigenori TAMAKI, Shuichi MURASHIMA, Hiroyasu KOBAYASHI, Hiroki YASUI, Tetsu KOBAYASHI, Osamu HATAJI, Yukihiko ADACHI; Role of nitric oxide in airway remodelling. Clin Sci (Lond) 1 March 2000; 98 (3): 291–294. doi: https://doi.org/10.1042/cs0980291
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