Naturally occurring hydroxystilbenes have been shown to induce vasorelaxation. Here, we studied the mechanism of resveratrol-induced vasorelaxation in different types of blood vessels, namely mesenteric (resistance) and main uterine (conductance) arteries, from female guinea-pigs on day 7 and day 15 of the oestrous cycle. Resveratrol (5–70 µmol/l) induced concentration-dependent relaxation of both mesenteric and uterine arteries preconstricted with either noradrenaline (NA; 10 µmol/l) or KCl (125 mmol/l). Resveratrol was 2-fold more potent in inducing relaxation of mesenteric arteries than of uterine arteries. Its effects on uterine arteries from both day-7 and day-15 guinea-pigs were similar, irrespective of the constrictor used, but it was significantly (P < 0.01) more potent in inducing relaxation of mesenteric arteries contracted with NA compared with those constricted with KCl. In day-7 arteries precontracted with NA, NG-nitro-l-arginine methyl ester (l-NAME; 10 µmol/l) had no effects on the time course of resveratrol-induced vasorelaxation in either mesenteric or uterine arteries. However, indomethacin (50 µmol/l) significantly (P < 0.05) potentiated resveratrol's effect on mesenteric, but not uterine, arteries. Indomethacin had no effect on resveratrol-induced vasorelaxation of arteries contracted with KCl, whereas l-NAME significantly (P < 0.05) reduced the effects of resveratrol on uterine, but not on mesenteric, arteries. In day-15 arteries, l-NAME significantly (P < 0.01) attenuated the effects of resveratrol on mesenteric arteries contracted with NA. Indomethacin had no effect on resveratrol activity. This study indicates that: (a) the effect of resveratrol on resistance arteries is greater than that on conductance arteries; (b) the effects of resveratrol are not mediated via prostanoids, but NO may play a role; and (c) the stage of the oestrous cycle has no influence on resveratrol-induced vasorelaxation.
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April 03 2000
Resveratrol induces vasorelaxation of mesenteric and uterine arteries from female guinea-pigs
Ebrahim K. NADERALI;
*Diabetes and Endocrinology Research Unit, Department of Medicine, University of Liverpool, University Clinical Department, Daulby Street, Liverpool L69 3GA, U.K.
Correspondence: Dr E. K. Naderali (e-mail [email protected]).
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Patrick J. DOYLE;
Patrick J. DOYLE
†Novo-Nordisk A/S, Brudelysvej 28, 2880 Bagsvaerd, Denmark
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Gareth WILLIAMS
Gareth WILLIAMS
*Diabetes and Endocrinology Research Unit, Department of Medicine, University of Liverpool, University Clinical Department, Daulby Street, Liverpool L69 3GA, U.K.
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Publisher: Portland Press Ltd
Received:
October 13 1999
Revision Received:
December 06 1999
Accepted:
January 12 2000
Online ISSN: 1470-8736
Print ISSN: 0143-5221
The Biochemical Society and the Medical Research Society © 2000
2000
Clin Sci (Lond) (2000) 98 (5): 537–543.
Article history
Received:
October 13 1999
Revision Received:
December 06 1999
Accepted:
January 12 2000
Citation
Ebrahim K. NADERALI, Patrick J. DOYLE, Gareth WILLIAMS; Resveratrol induces vasorelaxation of mesenteric and uterine arteries from female guinea-pigs. Clin Sci (Lond) 1 May 2000; 98 (5): 537–543. doi: https://doi.org/10.1042/cs0980537
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