Myoadenylate deaminase (MAD) is an enzyme active in skeletal muscle, probably during exercise of moderate intensity but certainly during vigorous exercise, when the deamination of AMP leads to increased levels of IMP and ammonia. There is controversy about the clinical significance of MAD deficiency. The main objective of the present study was to investigate the extent to which genetically confirmed MAD deficiency affects muscle function under conditions of maximal short-term electrically induced activation. The left hand was immobilized and adductor pollicis muscle function was investigated. To exclude the influence of central factors, such as the patient's motivation, the ulnar nerve was maximally electrically activated and force output was measured at the thumb. Sixty rapid shortening contractions resulted in a decrease of maximal power to 34.2±5.4% and 33.3±6.3% (means±S.D.) of the values for unfatigued muscle in the control and MAD-deficient subjects respectively (P > 0.05; n = 7). Maximal isometric forces and shortening velocities did not differ between groups in unfatigued, fatigued or recovered muscle. None of the subjects experienced exercise-related muscle aches or cramps. In conclusion, MAD deficiency does not appear to affect adductor pollicis muscle force, shortening velocity and relaxation, either during or after maximal short-term activation.
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Research Article|
April 05 2000
Muscle function during fatigue in myoadenylate deaminase-deficient Dutch subjects
C. J. DE RUITER;
*Institute for Fundamental and Clinical Human Movement Sciences, Vrije Universiteit, Van der Boechorststraat 9, 1081 BT Amsterdam, The Netherlands
Correspondence: Dr C. J. de Ruiter (e-mail [email protected]).
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B. G. M. VAN ENGELEN;
B. G. M. VAN ENGELEN
†Department of Neurology, University Hospital Nijmegen, Nijmegen, The Netherlands
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R. A. WEVERS;
R. A. WEVERS
†Department of Neurology, University Hospital Nijmegen, Nijmegen, The Netherlands
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A. DE HAAN
A. DE HAAN
*Institute for Fundamental and Clinical Human Movement Sciences, Vrije Universiteit, Van der Boechorststraat 9, 1081 BT Amsterdam, The Netherlands
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Publisher: Portland Press Ltd
Received:
June 21 1999
Revision Received:
November 29 1999
Accepted:
January 26 2000
Online ISSN: 1470-8736
Print ISSN: 0143-5221
The Biochemical Society and the Medical Research Society © 2000
2000
Clin Sci (Lond) (2000) 98 (5): 579–585.
Article history
Received:
June 21 1999
Revision Received:
November 29 1999
Accepted:
January 26 2000
Citation
C. J. DE RUITER, B. G. M. VAN ENGELEN, R. A. WEVERS, A. DE HAAN; Muscle function during fatigue in myoadenylate deaminase-deficient Dutch subjects. Clin Sci (Lond) 1 May 2000; 98 (5): 579–585. doi: https://doi.org/10.1042/cs0980579
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