Hyperventilation (HV) and respiratory alkalosis are associated with hypophosphataemia, although the extent and duration of HV required to produce changes in serum phosphate levels are not known. We sought to characterize the effects of HV, with or without dextrose loading, on serum phosphate levels and other biochemical parameters. HV was monitored by controlling the end-tidal partial pressure of carbon dioxide (Petco2). The effect of dextrose was studied because infusion of a glucose load is known to promote a fall in serum phosphate via stimulation of glycolysis. Eight healthy volunteers were enrolled in four study protocols: (1) HV for 20 min to a Petco2 of 25–30 mmHg (mild); (2) HV for 20 min to a Petco2 of 15–20 mmHg (severe); (3) mild HV with intravenous dextrose loading, and (4) dextrose loading alone. Periodic measurements of serum phosphate, venous pH, serum 2,3-diphosphoglycerate (2,3-DPG) and other parameters were made. Serum phosphate fell during HV and continued to decline after cessation of HV. Dextrose loading alone caused a fall in serum phosphate that continued for at least 30 min after cessation of the infusion (P < 0.0002). HV combined with dextrose resulted in a greater decline in serum phosphate than either variable alone (P = 0.003). The maximal decline in serum phosphate occurred in severe HV, with a mean decrease of 0.38 mmol/l at 20 min after cessation of HV (P < 0.0001). Serum phosphate was still significantly lowered compared with baseline at 90 min after cessation of HV (P = 0.001). Other significant changes seen with HV included a decrease in serum glucose (P < 0.01), a decrease in serum potassium (P < 0.05) and an increase in venous pH (P < 0.007). Serum 2,3-DPG levels did not change significantly in any study protocol. Thus relatively mild acute HV produces significant changes in serum phosphate. In both mild and severe HV this effect is progressive after cessation of HV. This phenomenon has not been shown before, and may have significant clinical implications.
Skip Nav Destination
Article navigation
Research Article|
April 26 2000
Persistent, progressive hypophosphataemia after voluntary hyperventilation
M. PALEOLOGOS;
M. PALEOLOGOS
1Department of Pulmonary and Critical Care Medicine, Manly Hospital and the University of Sydney, P.O. Box 465, Manly, NSW 2095, Australia
Search for other works by this author on:
E. STONE;
E. STONE
1Department of Pulmonary and Critical Care Medicine, Manly Hospital and the University of Sydney, P.O. Box 465, Manly, NSW 2095, Australia
Search for other works by this author on:
S. BRAUDE
1Department of Pulmonary and Critical Care Medicine, Manly Hospital and the University of Sydney, P.O. Box 465, Manly, NSW 2095, Australia
Correspondence: Dr S. Braude (e-mail [email protected]).
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
May 13 1999
Revision Received:
December 03 1999
Accepted:
February 18 2000
Online ISSN: 1470-8736
Print ISSN: 0143-5221
The Biochemical Society and the Medical Research Society © 2000
2000
Clin Sci (Lond) (2000) 98 (5): 619–625.
Article history
Received:
May 13 1999
Revision Received:
December 03 1999
Accepted:
February 18 2000
Citation
M. PALEOLOGOS, E. STONE, S. BRAUDE; Persistent, progressive hypophosphataemia after voluntary hyperventilation. Clin Sci (Lond) 1 May 2000; 98 (5): 619–625. doi: https://doi.org/10.1042/cs0980619
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Could not validate captcha. Please try again.
Biochemical Society Member Sign in
Sign InSign in via your Institution
Sign in via your InstitutionGet Access To This Article
Cited By
Open Access for all
We offer compliant routes for all authors from 2025. With library support, there will be no author nor reader charges in 5 journals. Check here |
![]() |